WARNING: LOSS OF BONE MINERAL DENSITY
- Women who use medroxyprogesterone acetate injectable suspension may lose significant bone mineral density. Bone loss is greater with increasing duration of use and may not be completely reversible.
- It is unknown if use of medroxyprogesterone acetate injectable suspension during adolescence or early adulthood, a critical period of bone accretion, will reduce peak bone mass and increase the risk for osteoporotic fracture in later life.
- Medroxyprogesterone acetate injectable suspension is not recommended as a long-term birth control method (i.e., longer than 2 years) unless other birth control methods are considered inadequate.