(segesterone acetate and ethinyl estradiol vaginal system)
Delivers 0.15 mg/0.013 mg per day

ANNOVERA is an annual contraceptive, inserted for 21 continuous days and removed for 7 days each cycle.

Afaxys is an authorized promotional partner for ANNOVERA®.



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Product Details

  • Long-term, procedure-free contraceptive: 1-year contraceptive vaginal ring with 21/7 day dosing for 13 cycles
  • Composed of a soft, pliable, “squishy” silicone elastomer (8.4 mm in cross section and 56 mm (2¼ inches) in diameter
  • Releases an approximate average 0.15 mg/day of segesterone acetate (SA) and 0.013 mg/day of ethinyl estradiol (EE) when placed in the vagina
  • Each carton contains 1 ANNOVERA vaginal system in a pouch; a black compact case is provided with the drug product for storage of ANNOVERA by patients during each 7-day system-out interval
  • When inserted before the expiration date indicated on the carton, ANNOVERA will last for the complete 13 cycles
  • Does not require refrigeration

Product Features:

  • A single contraceptive system that lasts for a full year, ANNOVERA is the long-lasting alternative to traditional LARCs.1
  • Predictable Scheduled Bleeding Profile2* - ANNOVERA is inserted for 21 continuous days and then removed for 7 days (13 cycles)
  • Easy Patient Experience - Soft, squishy, and easy to use - no larger than a tampon during insertion3
  • High Patient Satisfaction - ~90% of women were satisfied with ANNOVERA as a contraceptive, including 87% who were new to a vaginal ring4†
  • Novel hormone profile - ANNOVERA releases segesterone acetate, the only progestin in a combination hormonal contraceptive derived from natural progesterone rather than testosterone, and ultra-low-dose ethinyl estradiol.5

Visit for resources and tools to assist both you and your patients.

Explore the features of ANNOVERA: Watch the MEET ANNOVERA video

Introduce her to ANNOVERA: Watch the ANNOVERA Patient Educational video


*5-10% of females experienced unscheduled bleeding and/or spotting for ~1 day or less per 28-day cycle.

†In an ANNOVERA Phase 3 study, a product acceptability questionnaire was administered and completed at the end of Cycle 3 (n=1036). Results based on data from 905 subjects in the areas of ease-of-use, expulsion, side effects, and sex/intercourse.

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Distributor & Ordering Info


NDC#: 50261-313-01

Package Size: Box Containing 1 Vaginal System and 1 Storage Case

Distributor Phone URL Order Number
AmerisourceBergen 1-610-727-7000 10232079
ANDA 1-800-331-2632 (Ext. 74591) 392014
Cardinal Health 1-800-326-6457 5560172
McKesson 1-855-625-6285 3977816
Morris & Dickson 1-888-376-7409 766121
NC Mutual 363119
Prescription Supply 1-800-777-0761 970186
R & S Northeast 1-800-262-7770 50261-313-01
Smith Drug 1-800-572-1216 891887
Value Drug 1-800-252-3786 (Ext. 1) 216505

(segesterone acetate and ethinyl estradiol vaginal system)

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